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is difficult to say goodbye to the great Paul Newman

known for weeks that the end of Paul Newman was close, after the news of his fight against terminal cancer lung (initially denied even by the actor) asked his family to let him die in his home where he died Friday 26, winning the battle this sad disease. Its foundation today issued a statement of condolence in which he paid tribute.

" Paul took what life had to offer, and while he refused to acknowledge he was doing something special, I was actually changing the lives of a lot thanks to his generosity, humor and humanity. His legacy lives through charity has shown, "read the note from the vice president of Newman's Own Foundation, Robert Forrester.

Newman founded in 1982, the brand of food products 'Newman's Own', which began almost a joke in the basement of his home and the profits of that year were donated in full to charitable activities. It is estimated that to date the company exceeds 200 million (almost 137 million euros) in donations.

few hours before your foundation issued the statement, the president of the Foundation Limestre Dynamo Camp, Vincenzo Manes (Italy), and claimed that he had received an email from the U.S. in which he reported that Paul Newman " this morning I received an email from America where I have said that Paul Newman is no longer with us ."

Newman left the cinema in 2007, " I can not work more as an actor at the level that I would " said at the time, with more than 60 films in his career that earned him an Honorary Oscar in 1985, a year after finally receive as he said "a real Oscar" thing that I thought would never happen, the Oscar for Best Actor for his performance in The Color of Money. In addition

had multiple nominations and awards including the Jean Hersholt Humanitarian Award, also from the Academy Awards in 1993. Earned four Golden Globe Best Actor Series in 2006 Cecil B. Award DeMille in 1984, Best Director for Rachel, Rachel in 1969 and Golden Globe New Star of the Year in 1957 for The Silver Chalice.

The actor was also known for his boundless enthusiasm for automobile racing, where he also won awarded, a hobby that began after acting in the movie "Winning" in 1969.

mate in two of my favorite movies and his great friend Robert Redford says:
" I have lost a true friend. There comes a time when feelings can not be expressed in words. My life-and this country are better off because he . "

His daughters also made a statement:
" Paul Newman played many unforgettable roles. But he was most proud of never led the division on the marquee: loyal husband, loving father, grandfather, adorable, big-time philanthropist .

But surely always remember him for those stunning blue eyes and easy to make you believe any character. It was one of my favorite actors and will remain so forever, I can not keep from getting too bad to have died not know them personally but when a player comes to you that way, you feel that you will also no longer be affected.

At the time he announced he was leaving the film even with over many years and realizing that it deserved tranquility I felt sad, I guess they knew he was sick. And a curious fact, my father greatly resembles him, I guess that's why when you saw in his movies was so familiar to me. We'll always have that, his movies to remember him and admire his work, beyond that will be all set up foundations and companies to collaborate with the world how bad he is, it was also an actor was a man of great political consciousness, social and family.

His films will always be part of my cinematic memory will always be among my favorite movies and never missing in my collection of dvds.

News of his dismissal from the film and biography: Farewell film and biography.

When it was learned he was sick: News disease.



may not be a great honor but it is done with all my love and admiration for this great man and actor.

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Manolo Martinez

Today we will talk for the first time an athlete OsosFamosos . We know that the characters discussed in this blog are not just for his good physical condition, but today we will find the exception. Perhaps you have heard of him, for his achievements as an athlete or perhaps because of his brief appearance in the film "Cachorro " in the form of television pictures.

Manolo was born in Leon, a December 7 nearly 34 years, ie 1974. Manolo is known to be a English elite athlete in shot put, which came by chance. With only 12 years old, he devoted himself to look like other sport practiced until Carlos Burón prompted him to look at and try to stop himself. Today Carlos Buron is still the coach Manolo.

Manolo's curriculum has grown steadily since 1992, it had been done in Spain's champion in shot put junior, both in and outdoor track.

Throughout his career he has made with six gold medals in different competitions. His greatest achievement was obtained in the years 2002 and 2003 which was proclaimed Champion Europe and the world in shot put in track.

Her dream is to become Olympic champion, however, the Olympic medals have always resisted it, standing at the gates of the bronze medal at the Olympic Games of Athens 2004 and more discrete skills (two sevenths posts) in late '00 and Atlanta '96, Sydney. Despite that Manuel is an iconic native sport.

Regardless of sport, Manolo is devoted to painting, sculpting and writing. Has a studio and has exhibited many of his works. In paint falls within the conceptualism and many of his works stamped letters.

This muscular animal, which is capable of lifting up to 310 kilos, has the absolute record achieved national titles in indoor track, 13 in total.

many of us wish to be raised by this Osaze! Ay oma que rico!

Sources:

* Official Web

Manolo Martinez Manolo Martinez * Wikipedia

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"Celiac and psoriasis? Definitely maybe. Celebrities with psoriasis

Taken from the "National Psoriasis Foundation:

connection between psoriasis and celiac disease

Have you ever wondered if something in your diet that can worsen the psoriasis?. Many people have done. There are almost as many theories about diet and psoriasis as people with psoriasis. But scientists have never been convincingly demonstrated the effect of any particular diet on the disease. However, a growing body of research establishing that for a very small percentage of patients may be a connection between what is therefore important mouthed and what happens to your skin.

This connection may have to do with the pasta dish last night, with cereal this morning, with the donut noon in the office and the sandwich lunch. All of these foods contain gluten, which is insoluble component of grains of wheat, barley and rye. Some researchers believe that a very small subgroup of people with psoriasis may be celiac disease (gluten intolerance). Celiacs have the backing of the small intestine so badly damaged they can cause chronic diarrhea, nutritional problems and absorption of food and vitamin deficiencies. Celiac patients may experience abdominal cramping and pain, bone pain and joint pain, bloating, flatulence and fatigue among other symptoms.

No more pasta?

Researchers who have studied psoriasis and intolerance to gluten believe that people with both diseases could significantly improve their psoriasis using the only available treatment for celiac disease: a strict diet called GFD (Gluten-Free Diet). The diet requires a total and prolonged absence at the time of gluten leading to a radical change in eating habits. Avoid

gluten meal means giving as common as grains, beer, barley, anything made with wheat flour and pasta. A well Deita implies a change in lifestyle and the results may appear only after weeks or months of close monitoring. Gerald Krueger, MD Professor of Dermatology at the University of Utah, confirmed that no one should deceived by the GFD. "It's a very strict diet. People with a severe problem of celiac disease can tell you how hard it is." Research

psoriasis and gluten

In 1993 a study by Swedish scientists led by Gerd Michaelsson, MD, Ph.D., professor emeritus at the University of Uppsala in Sweden, found that 16% of patients with psoriasis had increased their antibodies to gliadin (gluten protein to which some people have a reaction). Elevated levels of these antibodies, called AGA, are an indicator of celiac disease.

The same researchers conducted another study, published in the British Journal of Dermatology in 2000, which evaluated the effect of a gluten-free diet in 33 people with psoriasis who had antibodies AGA (AGA +) compared to 5 people with psoriasis without (AGA-). Patients sugieron the GFD for 3 months, followed by 3 months of their ordinary diet. 30 of the 33 AGA + improved with the GFD, while none of the 6 patients AGA-noted improvements. When patients AGA returned to their eating habits ordinary psoriasis worsened for 18 of the 30 had improved.

According to Dr. Krueger, it is clear from these small experiments that many of the patients with psoriasis who are AGA + improved with the GFD. "There seems to increase in the frequency of celiac disease among people with psoriasis, "says Dr. Krueger." I firmly believe I have something here, given that both psoriasis and celiac disease appear to be autoimmune diseases Th-1 type. It believe that both diseases are caused by overactive T cells, or activated inappropriately in the skin in the case of psoriasis, and the gut in the case of celiac disease. This is an intriguing connection that has scientists estuciando both diseases in finding common links in the origin and treatment.

connection still in doubt.

However, the most basic math would dictate that surprising if there were no people with both diseases. "In fact," says Dr. Krueger, "a small percentage of normal people with celiac disease, and a small percentage of normal people with psoriasis, so do not be surprised to find a significant number of people who have both. The challenge is to determine if the connection is real. The difficulty in determining it is a problem of numbers: number of patients and number of dollars. It can be very difficult for researchers to gather enough patients to study a small subrgrupo of patients with a disease that affects only 2% of the general population. And it's very, very expensive "Meanwhile, it is very important to talk to your doctor about celiac disease and the GFD before changing your diet or treatment. Symptoms may or may not be present in people com both diseases. Dr. Michaelsson believes that, in fact, many people with psoriasis who are AGA + and are potentially benefit from the GFD may have no symptoms celiac disease, but instead could have what she calls "silent celiac disease"

"If you think Intolerance to gluten can affect you, particularmene if you have moderate to severe psoriasis or uncontrolled pustolosis palmoplantar, Dr. Krueger recommends that you discuss the situation thoroughly with your doctor. Talk about whether a monitoring on Celiac disease markers could be useful. These markers are present in the blood of a person with celiac disease has been exposed to gluten, but the markers disappear when gluten is removed from the diet.

is important to consult your doctor and make appropriate tests before starting a GFD, because following a GFD before having made the appropriate blood tests may jeopardize the accuracy of the tests. Many doctors want to perform blood tests and intestinal biopsy to confirm celiac disease. For patients with psoriasis with celiac disease, Dr. Krueger agrees with Dr. Michaelsson to recommend the GFD.

Psoriasis and gluten intolerance.
An interview with Dr. Gerd Michaelsson

What are the key pieces of evidence that celiac disease (or gluten intolerance) and psoriasis?

First, the majority of patients with psoriasis are not gluten intolerant. However, there is a subgroup with silent celiac disease is important to identify these patients, since there is a chance to improve their skin lesions trave's a gluten-free diet (GFD). Some patients may have a total or near total recovery from the diet. When gluten is reintroduced there is a worsening of psoriasis. The effect of diet also appears to be very positive for palmoplantar pustular psoriasis (PPP), again with worsening when gluten is reintroduced. Moreover, the main focus in the PPP is in the snuff, and that 95% of PPP patients are smokers at the onset of his illness. As for patients with psoriatic arthritis and intolerance to gluten, there is an improvement in the skin lesions and as for arthritis. But the effect on arthritis is less noticeable than on the skin, indicating that there may be other contributing factors associated with arthritis.

In your opinion, what percentage of people with psoriasis and / or psoriatic arthritis have this connection?

About 16% of patients with psoriasis vulgaris have antibodies against gliadin, which is a fraction of the gluten. It is interesting to note that we have not found patients with psoriasis vulgaris, without arthritis, which had been previously diagnosed with celiac disease. Probably celiac disease patients who follow a strict diet GFD do not develop psoriasis or it goes away with diet and these patients need not go to a dermatologist. Not all psoriasis patients with antibodies to gliadin have the disease Classic celiac, which is characterized by damage to the villi of the intestinal mucosa and pronounced inflammation. Some patients have only slight changes in the intestine with very discrete inflammatory bowel disease. They can still improve with GFD. However, the most dramatic improvement in psoriasis occurs in those with more pronounced changes in the intestinal mucosa. Some of these patients also have antibodies against the enzyme transglutanimasa. Among patients with arthritis the percentage of antibodies to gliadin is the same as in those with psoriasis vulgaris, but also found that 4% had been previously diagnosed with celiac disease which again indicates that the arthritis does not respond the same way to the skin GFD. The highest percentage of anticerpos to gliadin (20%) were found in patients with PPP. Preliminary data indicate a very good response to GFD in these patients.

What do you think may be the most likely explanation for the connection between the two diseases? Is it genetic or caused by other factors (such as T-cell activation, immune system, etc.)?

psoriasis patients who have gluten intolerance may belong to a genetic subgroup with an increased risk for psoriasis, celiac disease and illness thyroid (the latter association is particularly common in women with PPP). Possibly there may be one or more autoantigens that are relevant to inflammation in psoriasis. One of these possible autoantigens may be the enzyme transglutaminase is also related to the processing of gluten. The expression of this enzyme is increased in blood vessels of psoriatic lesions and this expression is reduced when patients adhere to the GFD.

you recommend to patients with psoriasis or psoriatic arthritis to seek any particular symptoms or taking any concrete action?

In patients who had not been previously diagnosed with gluten intolerance enconramos that none of them had a history of gastrointestinal complaints increased compared to those without gluten intolerance. We recommend that patients with severe psoriasis or palmoplantar pustulosis analyzing the presence of antibodies against gliadin and transglutaminase and IgA serum levels. Other indicators of celiac disease are low levels of iron, zinc and folic acid, but in patients with mild intestinal changes these parameters are usually normal. The test costs are low while the results can be very rewarding. So our first patients treated with psoriasis and silent celiac disease have 25 years clean!

More about:

Celiac Disease:

http://es.wikipedia.org/wiki/CelÃ-aca

psoriasis and celiac disease:

http://72.52.253.151/ ~ live / files / Caldero_n% 20Perla.% 20Estudio% 20of% 20EC% 20of% 20patients% 20with% 20psoriasis .. pdf