According this article in "The Pais:
identified two genes that determine
psoriasis is the LCE3C LCE3B and whose absence implies a 20% risk of developing this skin disease, according to a study by the Center for Genomic Regulation in Barcelona
Researchers at the Center for Genomic Regulation (CRG) in Barcelona have identified two genes whose absence involves more than a 20% risk of psoriasis. This makes the second genetic factor involved in the development of this disease.
To The study, published in the journal Nature Genetics, has been studied more than 2,500 samples of patients from Spain, Holland, Italy and the United States. Scientists have focused on exploring regions of the genome that vary in the number of copies of the genes they contain, as explained a spokesman for the CRG.
The investigation determined that patients with psoriasis are lacking, with a high frequency, the two copies of two genes known as LCE3B and LCE3C, which have a role in the formation of a functional epidermis.
Psoriasis is a chronic inflammatory disease of the skin that affects more than one million people in Spain and usually appear between 15 and 40 years, and it is due to a combination of factors and genetic ambienales.
The researchers' work has immediate implications CRG for the diagnosis and opens new avenues to explore preventive and curative treatments for a disease for which therapeutic tools are only palliative. Certain medications, infections, trauma, cold and stress are the main triggers of this skin disease, the study said, is more common among identical twins is a common disease in some families.
However, despite being identified genetic factors involved in predisposition to psoriasis, there are few factors common to multiple populations, probably because of the environment.
The publication of this research, directed by Xavier Estivill, Genes and Program Coordinator CRG disease, is accompanied by other two jobs, one of which says that genes are absent in populations of European origin CRG study may have a protective effect on the population China, in which psoriasis is very rare.
The researchers are now studying other processes that alterations of the barrier to entry of microorganisms and other agents can damage the skin and other tissues, and in which these genes may play a protective role.
